PRIMES > Research


Research

Background


At the National level, the questions of cancer and ageing are given highest priority in the domain of health research, providing strong societal impact for the quality of life and for the economy. Ageing-related diseases are part of the axes of the Research and Innovation National Strategy (SNRI) and the support to innovative radiotherapy is one of the recommendation points of the 2007-2013 Cancer Plan.

PRIMES is a LabEx project aiming at gathering a transdisciplinary community having expertise in nuclear and medical physics, radiobiology, medical imaging and computer science in the PRES of Lyon- Saint-Etienne and the extended Rhône-Alpes-Auvergne region.

While the biological and medical questions are well identified, this research relies more and more on new technologies for the understanding of the biological mechanisms, the early diagnosis of diseases, their therapeutic actions and their follow up. This area has been booming in the last years, with the availability of new imaging devices, progresses in image processing software, new radio-based therapies. However, despite the availability of a considerable amount of new image-information and new methods for therapy, there still are challenges and bottlenecks to successfully answer the biological and medical issues. Radiation therapy (RT) in Cancer is also a major area of research involving innovation in new ion-based or synchrotron therapy methods, the accurate preparation and control of the therapy, and a better understanding of the effects of high-dose (therapeutic efficiency) and low-dose (undesired to healthy tissues during treatment and imaging) irradiations.

The fundamental questions that are addressed in this project are how to provide new imaging tools for exploring living tissues at different scales with new contrasts and how to build optimized, controlled and safe strategies for irradiation-based cancer therapy.

These two broad research axes rely more and more on advances made in simulation and modeling associated to high performance computing. The wide availability of computing capabilities now brings simulation to a degree of realism that could not have been foreseen only a few years ago.
This field of research is by nature interdisciplinary and lies at the intersection of physics, biology, and information and communication science and technology.


PRIMES's scientific program


This program illustrates the multidisciplinary approach of PRIMES by developing cutting edge methods within five workpackages described below.