équipe BIORAN du Centre de Recherche en Neurosciences de Lyon

Our aims are to propose biochemical and radiopharmaceutical assays as brain biomarkers:
• to visualize and quantify pathophysiological targets in animal models and to contribute to transfer to patients;
• to propose innovative strategies to facilitate differential and early diagnostics;
• to accelerate the process from preclinical discovery to clinical phases.

Methods & Techniques
Molecular imaging: PET radiopharmacology and radiopharmacy, in vitro and in vivo animal imaging, neuropharmacology
Analytical neurochemistry and clinical biochemistry
Brain anatomopathology

Research projects
1. Receptors involved in cognition:
- New targets: serotonin 5-HT6, 5-HT7 receptors: from radiotracers to clinical phase I studies
- Functional 5-HT1A receptors: ligand/receptor interactions, functional mapping, endogenous 5-HT competition
2. Aggregated proteins involved in cognition:
- Biochemical and PET detection of α-synuclein
- Mechanisms of protein propagation