Thèse
Publié le 5 mars 2018 | Mis à jour le 19 septembre 2018

Shady KOTB 2013-2016 - PhD director: Olivier Tillement, co-director: Lucie Sancey

équipe ILM-FENNEC

Title: Nanoparticules théranostiques à base de Gadolinium : Optimisation et compréhension des mécanismes physiques et biologiques dans le traitement des tumeurs

Nanoparticles containing high-Z elements are known to boost the efficacy of radiation therapy. Gadolinium (Gd) is particularly attractive because this element is also a positive contrast agent for MRI, which allows for the simultaneous use of imaging to guide the irradiation and to delineate the tumor. Here, we used Silica-based gadolinium nanoparticle (Si-GdNP) -Known as AGuIX®- for brain melanoma metastases. After intravenous injection into animals bearing B16-F10 brain tumor, some Si-GdNP remained inside the tumor cells for more than 24 hours, indicating that a single administration of nanoparticle might be sufficient for several irradiations. Combining AGuIX® with radiation therapy increases tumor cell death in vitro, and improves the life spans of animals bearing multiple brain melanoma metastases. These results provide preclinical proof-of-concept for a phase I clinical trial.
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    Shady KOTB