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Unité de recherche

équipe BIORAN du Centre de Recherche en Neurosciences de Lyon

Our aims are to propose biochemical and radiopharmaceutical assays as brain biomarkers:
• to visualize and quantify pathophysiological targets in animal models and to contribute to transfer to patients;
• to propose innovative strategies to facilitate differential and early diagnostics;
• to accelerate the process from preclinical discovery to clinical phases.

Methods & Techniques
Molecular imaging: PET radiopharmacology and radiopharmacy, in vitro and in vivo animal imaging, neuropharmacology
Analytical neurochemistry and clinical biochemistry
Brain anatomopathology

Research projects
1. Receptors involved in cognition:
- New targets: serotonin 5-HT6, 5-HT7 receptors: from radiotracers to clinical phase I studies
- Functional 5-HT1A receptors: ligand/receptor interactions, functional mapping, endogenous 5-HT competition
2. Aggregated proteins involved in cognition:
- Biochemical and PET detection of α-synuclein
- Mechanisms of protein propagation

COORDONNÉES

Adresse :
BIORAN – Biomarqueurs radiopharmaceutiques et neurochimiques Centre de Recherche en Neurosciences de Lyon Inserm U1028 - CNRS UMR5292 Groupement Hospitalier Est - CERMEP 59 bd Pinel
69677 Bron

Organisation

Responsable(s)

Composition de l'équipe

Fabien CHAUVEAU CR CNRS
DENEROY Luc DR CNRS
FIEUX Sylvain TECH Lyon1
LANCELOT Sophie MCU-PH Lyon 1/ HCL
PINA-JOMIR Géraldine MCU-PH Lyon 1/ HCL
VERDURAND Mathieu CR HCL
ZEINYEH Wael MCU Lyon 1
ZIMMER Luc PU-PH Lyon 1/ HCL

Publications

Lien vers le site des publications de l'équipe